KMID : 1007520190280030907
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Food Science and Biotechnology 2019 Volume.28 No. 3 p.907 ~ p.911
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Postprandial anti-hyperglycemic effect of vitamin B6 (pyridoxine) administration in healthy individuals
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Kim Hyuk-Hwa
Kang Yu-Ri Choi Hwang-Yong Lee Jung-Yun Oh Jung-Bae Kim Justin S. Kim Young-Cheul Lee Ki-Won Kwon Young-In
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Abstract
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Postprandial blood glucose lowering effect of vitamin B6 (pyridoxine) was evaluated in healthy individuals with normal blood glucose levels. Blood glucose levels were measured every 30 min for 2 h after oral sugar administration with or without 50 mg of pyridoxine. Pyridoxine significantly lowered the postprandial blood glucose levels at 30 min (from 165.95?¡¾?17.19 to 138.36?¡¾?20.43, p?0.01) and 60 min (from 131.40?¡¾?17.20 to 118.50?¡¾?15.95) after administration. In addition, the area under the concentration?time curve (AUCt) was reduced by about 8.3% (from 257.08?¡¾?22.38 to 235.71?¡¾?12.33, p?0.05) and the maximum concentration of blood glucose (Cmax) was reduced by about 13.8% (from 165.95?¡¾?17.19 to 143.07?¡¾?11.34, p?0.01) when compared with those of the control group. Our findings suggest that pyridoxine supplementation may be beneficial for controlling postprandial hyperglycemia.
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KEYWORD
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Pyridoxine, Pyridoxine hydrochloride, Vitamin B6, Anti-hyperglycemic effects, Healthy individuals, Postprandial hyperglycemia
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